Overactive gene responsible for premature aging in Down syndrome

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New Delhi: Premature aging in patients with Down syndrome may be due to an overactive gene on chromosome 21, which changes DNA. inhibits the repair process and accelerates the symptoms associated with aging. This has been claimed in a new research led by UK-based Queen Mary University. According to the researchers, hyperactivity of a gene named ‘DYRK1A’ on an enzyme that accelerates chemical reactions in the body is caused by DNA. affects the repair mechanism.

This causes more damage to the DNA present in the cells and makes them more sensitive, thus speeding up the aging process. Patients with this non-hereditary genetic disorder look biologically 19.1 years older on average than their healthy peers and the aging process begins in childhood, the researchers said. The research results have been published in the recent issue of ‘Lancet discovery journal e-Biomedicine’. Lead researcher Dean Nijtic says that we have found that the trasomic hyperactivity of the ‘DYRK1A’ gene is a major cause of premature aging in patients with Down syndrome.

Additional research is needed to understand the extent to which this factor affects brain development and function. According to Nigetic, the research also showed that cell aging could be slowed down by controlling the activity of the ‘DYRK1A’ gene, which opens up the possibility of early therapeutic intervention for patients with Down syndrome. Globally, approximately 7 million people are estimated to suffer from Down syndrome.

Down syndrome is caused by an extra copy of chromosome 21 or trisomy 21.
According to researchers, Down syndrome is caused by the presence of an extra copy of chromosome 21 or trisomy 21. Adults born with this chromosome show early signs associated with the biological process of aging, such as decreased tissue regeneration, delayed wound healing, osteoporosis, degeneration of brain cells, and weakening of immune cells.

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